This film follows the making of Kevin Smith's latest film, Zack and Miri Make A Porno.

Ollie Trinkie is a publicist, who has a great girlfriend, Gertrude, whom he marries and they are expecting a baby but while he is looking forward to being a father, he doesn't lighten his workload. Gertrude gives birth but dies in the process. Ollie doesn't live up to his responsibilities as a father. Eventually the strain and pressure of losing his wife and being a father gets to him and he has breakdown, which leads to his termination. So with nothing much to do he tries to be good father to his daughter, Gertie. He also meets a young woman name Maya, who likes him but he is still not over his wife.

A calamity at Dante and Randall's shops sends them looking for new horizons - but they ultimately settle at Mooby's, a fictional fast-food restaurant. Free from his dead-end job (and lodged in a new one), Dante begins to break free of his rut, planning to move away with his clingy fiancé. Dante is ready to leave the horrors of minimum-wage New Jersey behind, but Randal - always the more hostile of the two - starts to become overwhelmed by his own rancor.

Zack and Miri are two lifelong platonic friends who make an adult film to pay the rent of their apartment. With their friend Delaney, the couple set out for auditionees for their porn film, but in the process of filming, they realize they feel more for each other than they had before.